Anti-inflammatory properties of quebecol and its derivatives

Bioorg Med Chem Lett. 2016 Jan 15;26(2):440-444. doi: 10.1016/j.bmcl.2015.11.096. Epub 2015 Nov 27.

Abstract

Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-κB activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-α. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure-activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol.

Keywords: Anti-inflammatory activity; Inhibition of NF-κB activation; Inhibition of cytokine secretion; Natural polyphenol; Quebecol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acer / chemistry*
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Humans
  • Interleukin-6 / immunology
  • Lipopolysaccharides / immunology
  • Macrophages / drug effects
  • Macrophages / immunology
  • NF-kappa B / immunology
  • Polyphenols / chemistry*
  • Polyphenols / pharmacology*
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Inflammatory Agents
  • Interleukin-6
  • Lipopolysaccharides
  • NF-kappa B
  • Polyphenols
  • Tumor Necrosis Factor-alpha