Heart disease modelling adds a Notch to its belt

Nat Cell Biol. 2016 Jan;18(1):3-5. doi: 10.1038/ncb3294.


The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.

Publication types

  • Comment

MeSH terms

  • Heart Ventricles / metabolism*
  • Humans
  • Organogenesis / physiology*
  • Receptors, Notch / metabolism*


  • Receptors, Notch