Serotnin as a possible biomarker in obstructive sleep apnea

Melissa C Lipford; Kannan Ramar; Yao-Jen Liang; Chii-Wann Lin; Yun-Ting Chao; Jen An; Chih-Hsien Chiu; Yi-Ju Tsai; Chih-Hung Shu; Fei-Peng Lee; Rayleigh Ping-Ying Chiang

doi:10.1016/j.smrv.2015.08.003

Serotnin as a possible biomarker in obstructive sleep apnea

Sleep Med Rev. 2016 Aug:28:125-32. doi: 10.1016/j.smrv.2015.08.003. Epub 2015 Aug 15.

Authors

Affiliations

¹ Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA.
² International Sleep Science & Technology Association, Berlin, Germany; Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan.
³ International Sleep Science & Technology Association, Berlin, Germany; Graduate Institute of Bioelectronics and Bioinformatics, National Taiwan University, Taiwan; Graduate Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
⁴ Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
⁵ Graduate Institute of Bioelectronics and Bioinformatics, National Taiwan University, Taiwan.
⁶ Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.
⁷ School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
⁸ Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
⁹ Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
¹⁰ International Sleep Science & Technology Association, Berlin, Germany; Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan; Sleep Technology Special Interest Group, INSIGHT Center, National Taiwan University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: rayleighchiang@ntu.edu.tw.

PMID: 26694311
DOI: 10.1016/j.smrv.2015.08.003

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.

Keywords: Alternative OSA treatments; Biomarkers; Obstructive sleep apnea (OSA); Polysomnography; Serotonin (5-HT); Sleep-disordered breathing.

Publication types

Review

MeSH terms

Biomarkers / metabolism
Humans
Respiratory System / physiopathology
Serotonin / metabolism*
Sleep
Sleep Apnea, Obstructive / metabolism*

Substances

Biomarkers
Serotonin