NK cells and cancer: you can teach innate cells new tricks

Nat Rev Cancer. 2016 Jan;16(1):7-19. doi: 10.1038/nrc.2015.5.


Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic function that provide host defence against microbial infection and tumours. Here, we review evidence for the role of NK cells in immune surveillance against cancer and highlight new therapeutic approaches for targeting NK cells in the treatment of cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Humans
  • Killer Cells, Natural / physiology*
  • Ligands
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Receptors, Natural Killer Cell / physiology


  • Ligands
  • Receptors, Natural Killer Cell