Alcohol and HIV Effects on the Immune System

Alcohol Res. 2015;37(2):287-97.


HIV disease and alcohol independently influence the human immune system, so it stands to reason that, together, their influence may be additive. Here, we review the evidence that alcohol can exacerbate HIV's influence on the immune system, thereby affecting disease progression and transmission. We focus particularly on alcohol's effect on the mucosal immune system in the tissues of the gastrointestinal tract, the genital tract and the lungs, all of which play a role in transmission and progression of HIV disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alcohol Drinking / immunology*
  • Alcoholism / complications
  • Alcoholism / immunology*
  • Disease Progression
  • Gastrointestinal Tract / immunology*
  • HIV Infections / complications
  • HIV Infections / immunology*
  • HIV Infections / transmission
  • Humans
  • Immunity, Mucosal / immunology*