Age peculiarities of reproductive morbidity in female participants of the ChNPP accident consequences clean up (according to the figures from SRU, 1988-2012 survey period)

Probl Radiac Med Radiobiol. 2015 Dec;20:366-75.
[Article in En, Ukrainian]

Abstract
in En , Ukrainian

Objective: to assess and estimate the peculiarities of genital system morbidity in female participants of the ChNPP accident clean up works in 1986-1987 depending on age at exposure to ionizing radiation and time since exposure.

Materials and methods: Data on the Chernobyl disaster survivors received from the State Registry of Ukraine are out line in the paper. Review of the level and pattern of genital system morbidity was carried out for the 17,237 female participants of the ChNPP accident clean up works in 1986-1987 depending on time under risk upon radiation expo sure and reproductive age at exposure. Survey period lasted since 1988 till 2012. Assessment of morbidity level, con fidential intervals, and statistical significance was carried out using the trial version of ОpenEpiversion 2.3.1. soft ware. Statistical significance was also rated using the z score and t criterion.

Results: The results of this cohort epidemiological study showed that there are some peculiarities of natural course of the female genital system disease depending on reproductive age at exposure and time under risk upon radiation impact. Comparative statistical review of the level and pattern of genital system morbidity at different times within a survey period.

Conclusion: Exposure to ionizing radiation in the childbearing age (18-45 years old) can be a risk factor of elevated incidence of uterine leiomyoma, benign mammary dysplasia (i.e. benign breast disease), and salpingo oophoritis. It is far to assume that uterine and mammary tissues are more sensitive to impact of ionizing radiation in females of the childbearing age vs. in persons exposed in pre menopause or menopause.

Meta: vyznachyty ta otsinyty osoblyvosti zakhvoriuvanosti statevoI systemy u zhinok uchasnyts' likvidatsiI naslidkiv avariI na ChAES 1986–1987 rr. zalezhno vid reproduktyvnogo viku na moment oprominennia ta chasu pislia opromi nennia.Materialy i metody. U statti predstavleno dani Derzhavnogo reiestru UkraIny osib, iaki postrazhdaly vnaslidok Chornobyl's'koI katastrofy. Provedeno analiz rivnia i struktury zakhvoriuvanosti statevoI systemy u 17237 zhinok uchasnyts' likvidatsiI naslidkiv avariI na ChAES 1986–1987 rr. zalezhno vid chasu perebuvannia pid ryzykom pislia oprominennia i reproduktyvnogo viku v moment oprominennia. Period monitoryngu 1988–2012 rr. Dlia vyz nachennia rivnia zakhvoriuvanosti, dovirchykh intervaliv i virogidnosti riznytsi vykorystano probnu versiiu programy OpenEpiversion 2.3.1., virogidnist' riznytsi vyznachalas' z vykorystanniam kryteriIv z score i t.Rezul'taty. Rezul'taty kogortnogo epidemiologichnogo doslidzhennia vyiavyly osoblyvosti rozvytku khvorob zhino choI statevoI systemy zalezhno vid reproduktyvnogo viku na moment oprominennia ta chasu perebuvannia pid ryzy kom pislia oprominennia. Provedeno porivnial'nyy statystychnyy analiz rivnia i struktury zakhvoriuvanosti state voI systemy za riznyy period chasu sposterezhennia.Vysnovok. Faktorom ryzyku zbil'shennia zakhvoriuvanosti na leyomiomy matky, dobroiakisni dysplaziI molochnoI zalozy, sal'pingooforyty mozhe buty oprominennia u reproduktyvnomu vitsi (18–45 r.). Mozhna prypustyty, shcho tkanyny matky ta molochnoI zalozy u zhinok, oprominenykh u reproduktyvnomu vitsi bil'sh chutlyvi na vplyv radiatsiynogo oprominennia, nizh u zhinok, iaki buly oprominenni u premenopauzi ta menopauzi.

Keywords: female participants of the ChNPP accident clean up; genital system disease; ionizing radiation.