Mass Eradication of Helicobacter pylorito Prevent Gastric Cancer: Theoretical and Practical Considerations

Gut Liver. 2016 Jan;10(1):12-26. doi: 10.5009/gnl15091.


Although the age-adjusted incidence of gastric cancer is declining, the absolute number of new cases of gastric cancer is increasing due to population growth and aging. An effective strategy is needed to prevent this deadly cancer. Among the available strategies, screen-and-treat for Helicobacter pylori infection appears to be the best approach to decrease cancer risk; however, implementation of this strategy on the population level requires a systematic approach. The program also must be integrated into national healthcare priorities to allow the limited resources to be most effectively allocated. Implementation will require adoption of an appropriate screening strategy, an efficient delivery system with a timely referral for a positive test, and standardized treatment regimens based on clinical efficacy, side effects, simplicity, duration, and cost. Within the population, there are subpopulations that vary in risk such that a "one size fits all" approach is unlikely to be ideal. Sensitivity analyses will be required to identify whether the programs can be utilized by heterogeneous populations and will likely require adjustments to accommodate the needs of subpopulations.

Keywords: Eradication; Helicobacter pylori; Population screening; Stomach neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Health Priorities
  • Helicobacter Infections / complications
  • Helicobacter Infections / diagnosis
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / therapy*
  • Helicobacter pylori
  • Humans
  • Mass Screening
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / prevention & control*