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Review
. 2015 Dec 22;8:44.
doi: 10.1186/s13040-015-0075-z. eCollection 2015.

Non-coding Yet Non-Trivial: A Review on the Computational Genomics of lincRNAs

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Free PMC article
Review

Non-coding Yet Non-Trivial: A Review on the Computational Genomics of lincRNAs

Travers Ching et al. BioData Min. .
Free PMC article

Abstract

Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.

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