Prevalence of blood eosinophilia in hospitalized patients with acute exacerbation of COPD

Respirology. 2016 May;21(4):761-4. doi: 10.1111/resp.12724. Epub 2015 Dec 23.


In this cohort of 3084 patients hospitalized for acute exacerbation of COPD (AECOPD), we found that 17% had blood eosinophilia (≥300 cells/μL); the use of an alternative cut-off level (≥2%) demonstrated that 40% had elevated eosinophil count. Patients with eosinophilia had higher frequency of readmission for AECOPD during 1-year follow-up period. This is the first study to investigate the prevalence of eosinophilia among inpatients with AECOPD--the population with the highest morbidity and health-care utilization.

Keywords: chronic obstructive pulmonary disease; eosinophilia; hospitalization; mortality; readmission.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Eosinophilia / blood*
  • Eosinophilia / epidemiology*
  • Eosinophils*
  • Female
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Patient Readmission / statistics & numerical data
  • Prevalence
  • Pulmonary Disease, Chronic Obstructive / epidemiology*
  • Pulmonary Disease, Chronic Obstructive / physiopathology