Evaluation of vitamin D levels in women with carpal tunnel syndrome

J Hand Surg Eur Vol. 2016 Jul;41(6):643-7. doi: 10.1177/1753193415622732. Epub 2015 Dec 23.


Studies suggest that vitamin D has a role in neuroprotection. We investigated whether vitamin D status is associated with carpal tunnel syndrome. Vitamin D levels were compared between carpal tunnel syndrome women (n = 135) and healthy control women (n = 135) or patients with other upper limb conditions (n = 135). There were no differences in vitamin D levels between the patients with carpal tunnel syndrome and the controls. However, women with carpal tunnel syndrome younger than 50 years old had significantly lower vitamin D levels than age-matched healthy control women (P = 0.023) or patients with other upper limb conditions (P = 0.035). When women with carpal tunnel syndrome and healthy control women were pooled, the incidence of carpal tunnel syndrome was higher in vitamin D deficient women than in non-deficient women, especially in those younger than 50 years. This study suggests a potential link between vitamin D status and the occurrence of carpal tunnel syndrome in women younger than 50 years but causation is not established.

Type of study/level of evidence: Prognostic Level III.

Keywords: Vitamin D; carpal tunnel syndrome.

MeSH terms

  • Adult
  • Age Factors
  • Carpal Tunnel Syndrome / blood*
  • Carpal Tunnel Syndrome / epidemiology*
  • Case-Control Studies
  • Female
  • Humans
  • Incidence
  • Middle Aged
  • Sex Factors
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / diagnosis


  • Vitamin D
  • 25-hydroxyvitamin D