Altered Brain Activation in a Reversal Learning Task Unmasks Adaptive Changes in Cognitive Control in Writer's Cramp

Neuroimage Clin. 2015 Nov 23;10:63-70. doi: 10.1016/j.nicl.2015.11.006. eCollection 2016.

Abstract

Previous receptor binding studies suggest dopamine function is altered in the basal ganglia circuitry in task-specific dystonia, a condition characterized by contraction of agonist and antagonist muscles while performing specific tasks. Dopamine plays a role in reward-based learning. Using fMRI, this study compared 31 right-handed writer's cramp patients to 35 controls in reward-based learning of a probabilistic reversal-learning task. All subjects chose between two stimuli and indicated their response with their left or right index finger. One stimulus response was rewarded 80%, the other 20%. After contingencies reversal, the second stimulus response was rewarded in 80%. We further linked the DRD2/ANKK1-TaqIa polymorphism, which is associated with 30% reduction of the striatal dopamine receptor density with reward-based learning and assumed impaired reversal learning in A + subjects. Feedback learning in patients was normal. Blood-oxygen level dependent (BOLD) signal in controls increased with negative feedback in the insula, rostral cingulate cortex, middle frontal gyrus and parietal cortex (pFWE < 0.05). In comparison to controls, patients showed greater increase in BOLD activity following negative feedback in the dorsal anterior cingulate cortex (BA32). The genetic status was not correlated with the BOLD activity. The Brodmann area 32 (BA32) is part of the dorsal anterior cingulate cortex (dACC) that plays an important role in coordinating and integrating information to guide behavior and in reward-based learning. The dACC is connected with the basal ganglia-thalamo-loop modulated by dopaminergic signaling. This finding suggests disturbed integration of reinforcement history in decision making and implicate that the reward system might contribute to the pathogenesis in writer's cramp.

Keywords: Basal ganglia; DRD2/ANKK1-TaqIa polymorphism; Functional magnetic resonance imaging; Probabilistic response; Reversal learning; Reward; Striatum; Task specific dystonia; Writer's cramp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Adult
  • Aged
  • Basal Ganglia / physiopathology
  • Brain / physiopathology*
  • Brain Mapping
  • Cognition / physiology*
  • Dystonic Disorders / genetics*
  • Dystonic Disorders / physiopathology*
  • Female
  • Formative Feedback*
  • Genotype
  • Gyrus Cinguli / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Protein-Serine-Threonine Kinases / genetics
  • Receptors, Dopamine D2 / genetics
  • Reversal Learning / physiology*
  • Young Adult

Substances

  • DRD2 protein, human
  • Receptors, Dopamine D2
  • ANKK1 protein, human
  • Protein-Serine-Threonine Kinases