Foundations of MRI phase imaging and processing for Quantitative Susceptibility Mapping (QSM)

Z Med Phys. 2016 Mar;26(1):6-34. doi: 10.1016/j.zemedi.2015.10.002. Epub 2015 Dec 15.


Quantitative Susceptibility Mapping (QSM) is a novel MRI based technique that relies on estimates of the magnetic field distribution in the tissue under examination. Several sophisticated data processing steps are required to extract the magnetic field distribution from raw MRI phase measurements. The objective of this review article is to provide a general overview and to discuss several underlying assumptions and limitations of the pre-processing steps that need to be applied to MRI phase data before the final field-to-source inversion can be performed. Beginning with the fundamental relation between MRI signal and tissue magnetic susceptibility this review covers the reconstruction of magnetic field maps from multi-channel phase images, background field correction, and provides an overview of state of the art QSM solution strategies.

Keywords: MRI phase; MRT-Phase; Magnetische Suszeptibilität; Phasenprozessierung; QSM; magnetic susceptibility; phase processing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Fields*
  • Magnetic Resonance Imaging / methods*
  • Models, Biological*
  • Radiation Dosage
  • Radiometry / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity