Warts Opens Up for Activation

Samuel A Manning; Kieran F Harvey

doi:10.1016/j.devcel.2015.12.004

Warts Opens Up for Activation

Dev Cell. 2015 Dec 21;35(6):666-8. doi: 10.1016/j.devcel.2015.12.004.

Authors

Samuel A Manning¹, Kieran F Harvey²

Affiliations

¹ Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia.
² Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia; Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: kieran.harvey@petermac.org.

PMID: 26702824
DOI: 10.1016/j.devcel.2015.12.004

Abstract

Warts is the central effector kinase of the Hippo growth-control pathway. In this issue of Developmental Cell, by assessing Warts conformation in vivo, Vrabioiu and Struhl (2015) report that the Mob family protein Mats regulates Warts activity allosterically, independent of phosphorylation by Hippo.

Publication types

Comment

MeSH terms

Animals
Drosophila Proteins / metabolism*
Drosophila melanogaster / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction*
Wings, Animal / growth & development*

Substances

Drosophila Proteins
Protein Serine-Threonine Kinases