Sperm DNA Methylation: Not a Vehicle for Dietary Reprogramming of Offspring?

Dev Cell. 2015 Dec 21;35(6):668-9. doi: 10.1016/j.devcel.2015.12.005.


Reporting in Developmental Cell, Shea et al. (2015) show, using an inbred mouse strain, that "epivariation"-stochastic individual differences in DNA methylation-is a much greater contributor to the sperm methylome than is diet. They conclude that DNA methylation is not the mechanism underlying the dietary reprogramming of offspring phenotype.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA, Ribosomal / genetics*
  • Epigenesis, Genetic / genetics*
  • Genetic Variation*
  • Genome / genetics*
  • Male
  • Spermatozoa / metabolism*


  • DNA, Ribosomal