Hemozoin Detection for Human Malaria Diagnosis Investigated in Rodent Models: How Similar Is Similar?

Trends Parasitol. 2016 Feb;32(2):94-96. doi: 10.1016/j.pt.2015.11.012. Epub 2015 Dec 17.

Abstract

New malaria diagnostic methods based on hemozoin (Hz) detection have been reported recently and were investigated in rodent models. These models are likely to produce unduly favorable results compared to the reality of Plasmodium falciparum malaria. Thus, for malaria diagnostics, results from rodent malaria experiments must be interpreted with caution.

Keywords: diagnosis; hemozoin; laboratory medicine; malaria; rodent models; validation studies.

MeSH terms

  • Animals
  • Diagnostic Techniques and Procedures / standards
  • Disease Models, Animal
  • Hemeproteins / analysis*
  • Humans
  • Malaria, Falciparum / blood
  • Malaria, Falciparum / diagnosis*
  • Plasmodium falciparum
  • Reproducibility of Results

Substances

  • Hemeproteins
  • hemozoin