A Spinal Circuit for Mechanically-Evoked Itch

Trends Neurosci. 2016 Jan;39(1):1-2. doi: 10.1016/j.tins.2015.12.001. Epub 2015 Dec 17.


A satisfactory neurobiological understanding of itch has proved difficult to reach. Bourane et al. have now uncovered a previously unrecognized spinal circuit for mechanically-induced itch and elucidated a mechanism that keeps it in check. Dysregulation of this circuit could contribute to chronic itch, suggesting a new strategy for itch relief.

Keywords: Itch; mechanoreceptor; pain; scratch; spinal; touch.

Publication types

  • Comment

MeSH terms

  • Animals
  • Interneurons / physiology*
  • Mechanotransduction, Cellular / physiology*
  • Neural Inhibition*
  • Pruritus / physiopathology*
  • Spinal Cord / physiology*
  • Synaptic Transmission*