LymPHOS 2.0: an update of a phosphosite database of primary human T cells

Database (Oxford). 2015 Dec 26:2015:bav115. doi: 10.1093/database/bav115. Print 2015.

Abstract

LymPHOS is a web-oriented database containing peptide and protein sequences and spectrometric information on the phosphoproteome of primary human T-Lymphocytes. Current release 2.0 contains 15 566 phosphorylation sites from 8273 unique phosphopeptides and 4937 proteins, which correspond to a 45-fold increase over the original database description. It now includes quantitative data on phosphorylation changes after time-dependent treatment with activators of the TCR-mediated signal transduction pathway. Sequence data quality has also been improved with the use of multiple search engines for database searching. LymPHOS can be publicly accessed at http://www.lymphos.org. Database URL: http://www.lymphos.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cells, Cultured
  • Databases as Topic*
  • Gene Ontology
  • Humans
  • MAP Kinase Signaling System
  • Molecular Sequence Data
  • Phosphopeptides / chemistry
  • Phosphopeptides / metabolism*
  • Proteome / metabolism
  • T-Lymphocytes / metabolism*

Substances

  • Phosphopeptides
  • Proteome