Telomere and telomerase stability in human diseases and cancer

Front Biosci (Landmark Ed). 2016 Jan 1;21(1):203-24. doi: 10.2741/4385.


Telomeres are the nucleoprotein structures at the end of linear eukaryotic chromosomes required for genome stability. Telomerase is the specialized enzyme deputed to their elongation. Maintenance of a proper telomere structure, an accurate regulation of telomerase biogenesis and activity, as well as a correct telomere-telomerase interaction and a faithful telomeric DNA replication are all processes that a cell has to precisely control to safeguard its functionality. Here, we review key factors that play a role in the development of these processes and their relationship with human health.

Publication types

  • Review

MeSH terms

  • Disease / genetics*
  • Humans
  • Neoplasms / enzymology
  • Neoplasms / genetics*
  • Telomerase / metabolism*
  • Telomere*


  • Telomerase