Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators

J Biochem. 2016 Mar;159(3):287-94. doi: 10.1093/jb/mvv123. Epub 2015 Dec 28.

Abstract

Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.

Keywords: MAML; Mastermind; Notch signalling; signal transduction; transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Humans
  • Mice
  • Mice, Knockout
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Oncogene Proteins, Fusion / genetics
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • MAML1 protein, human
  • MAML2 protein, human
  • MAML3 protein, human
  • MAML3 protein, mouse
  • MECT1-MAML2 fusion protein, human
  • Maml1 protein, mouse
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Receptors, Notch
  • Trans-Activators
  • Transcription Factors
  • mam protein, Drosophila