Cbx4: A new guardian of p63's domain of epidermal control

J Cell Biol. 2016 Jan 4;212(1):9-11. doi: 10.1083/jcb.201512032. Epub 2015 Dec 28.


Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Lineage*
  • Epithelial Cells / cytology*
  • Epithelial Cells / metabolism*
  • Epithelium / metabolism*
  • Polycomb Repressive Complex 1 / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*


  • Polycomb Repressive Complex 1
  • Ubiquitin-Protein Ligases