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, 290, 22-5

IL-8 and IL-6 Primarily Mediate the Inflammatory Response in Fibromyalgia Patients

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IL-8 and IL-6 Primarily Mediate the Inflammatory Response in Fibromyalgia Patients

Danelia Mendieta et al. J Neuroimmunol.

Abstract

Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.

Keywords: FIQ; Fibromyalgia; IL-6; IL-8; Inflammation.

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