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Review
, 24 (4), 301-11

New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences

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Review

New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences

Olga Peñagarikano. Exp Neurobiol.

Abstract

Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature.

Keywords: ASD; Autism; Pharmacotherapy; Repetitive behavior; Social behavior; Treatment.

Figures

Fig. 1
Fig. 1. Schematic representation of the strategies used to guide ASD treatment. Non-targeted treatments are directed towards treating symptomatology rather than underlying neurobiology and allow for management of associated maladaptive behaviors (left). On the other hand, the integration of multiple research approaches, from human studies to animal models based on human genetic findings converge in a deeper understanding of ASD pathophysiology guiding the development of novel more focused targeted treatments.

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