The Role of Oxidative Stress in Neurodegenerative Diseases

Exp Neurobiol. 2015 Dec;24(4):325-40. doi: 10.5607/en.2015.24.4.325. Epub 2015 Oct 12.


Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.

Keywords: Alzheimer's disease; Antioxidant; Neurodegenerative disease; Oxidative stress; Parkinson's disease; Reactive oxygen species.

Publication types

  • Review