Update on the epidemiology of multiple sclerosis

Mayo Clin Proc. 1989 Jul;64(7):808-17. doi: 10.1016/s0025-6196(12)61754-6.


Neuroepidemiology has been important in providing clues about the cause and pathogenesis of multiple sclerosis. In this review, we update the incidence and prevalence rates of multiple sclerosis in Olmsted County, Minnesota, and examine the potential role of viruses, exposure to animals, toxins, trauma, and diet in the development of this disease. Diseases of probable autoimmune nature have also been linked to multiple sclerosis. These descriptive data may contribute to the formulation of testable specific hypotheses about the pathogenesis and treatment of multiple sclerosis and other demyelinating diseases.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Communicable Diseases / complications
  • Female
  • Global Health
  • Humans
  • Male
  • Metals / adverse effects
  • Minnesota
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / etiology
  • Sex Factors
  • Transients and Migrants
  • Wounds and Injuries / complications


  • Metals