How good can cryo-EM become?

doi:10.1038/nmeth.3695

. 2016 Jan;13(1):28-32.

doi: 10.1038/nmeth.3695.

How good can cryo-EM become?

Robert M Glaeser¹

Affiliations

PMID: 26716559
DOI: 10.1038/nmeth.3695

How good can cryo-EM become?

Robert M Glaeser. Nat Methods. 2016 Jan.

. 2016 Jan;13(1):28-32.

doi: 10.1038/nmeth.3695.

Author

Robert M Glaeser¹

Affiliation

¹ Lawrence Berkeley National Laboratory, University of California, Berkeley, California, USA.

PMID: 26716559
DOI: 10.1038/nmeth.3695

Abstract

The suddenness with which single-particle cryo-electron microscopy (cryo-EM) has emerged as a method for determining high-resolution structures of biological macromolecules invites the questions, how much better can this technology get, and how fast is that likely to happen? Though we can rightly celebrate the maturation of cryo-EM as a high-resolution structure-determination tool, I believe there still are many developments to look forward to.

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References

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[1] Nature. 2015 Sep 10;525(7568):172-4 - PubMed

[2] Nature. 2015 Sep 10;525(7568):172-4 - PubMed

[3] J Struct Biol. 2014 Jul;187(1):1-9 - PubMed

[4] J Struct Biol. 2014 Jul;187(1):1-9 - PubMed

[5] J Mol Biol. 2003 Oct 31;333(4):721-45 - PubMed

[6] J Mol Biol. 2003 Oct 31;333(4):721-45 - PubMed

[7] Ultramicroscopy. 1984;14(3):219-26 - PubMed

[8] Ultramicroscopy. 1984;14(3):219-26 - PubMed

[9] Elife. 2014 Aug 13;3:e03665 - PubMed

[10] Elife. 2014 Aug 13;3:e03665 - PubMed

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How good can cryo-EM become?

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