Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial

J Contemp Dent Pract. 2015 Nov 1;16(11):880-3. doi: 10.5005/jp-journals-10024-1776.


Aim: The present study was designed to assess the effect of toothpaste containing neem on plaque and gingivitis.

Materials and methods: Randomized, double blind clinical trial was designed. Thirty first year dental students volunteered to participate in the study. Neem containing tooth paste was used as an intervention. Clinical examination was carried out using Silness and Loe plaque index (PI) and Loe and Silness gingival index (GI). Independent t-test and paired t-test was used for the intergroup and the intragroup comparison.

Results: Out of 30 participants, 22 (73.3%) were females and eight (26.7%) were males. A statistically significant difference was found between the test and control group after intervention with respect to the PI and GI.

Conclusion: Neem containing toothpaste can be used as an adjunct for maintenance of oral hygiene.

Clinical significance: Regular brushing with neem toothpaste might act as an adjunct to maintenance of good oral hygiene, and thus improve oral health.

Keywords: Gum bleeding; Herbal dentifrice; Parallel study design; Tooth deposits.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dental Plaque / drug therapy*
  • Dental Plaque Index
  • Double-Blind Method
  • Female
  • Gingivitis / drug therapy*
  • Humans
  • Male
  • Periodontal Index
  • Toothpastes / therapeutic use*
  • Treatment Outcome
  • Young Adult


  • Toothpastes