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Clinical Trial
. 2016 Feb;103(2):341-7.
doi: 10.3945/ajcn.115.123281. Epub 2015 Dec 30.

Comparison of the DASH (Dietary Approaches to Stop Hypertension) Diet and a Higher-Fat DASH Diet on Blood Pressure and Lipids and Lipoproteins: A Randomized Controlled Trial

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Free PMC article
Clinical Trial

Comparison of the DASH (Dietary Approaches to Stop Hypertension) Diet and a Higher-Fat DASH Diet on Blood Pressure and Lipids and Lipoproteins: A Randomized Controlled Trial

Sally Chiu et al. Am J Clin Nutr. .
Free PMC article

Abstract

Background: The DASH (Dietary Approaches to Stop Hypertension) dietary pattern, which is high in fruit, vegetables, and low-fat dairy foods, significantly lowers blood pressure as well as low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol.

Objective: The study was designed to test the effects of substituting full-fat for low-fat dairy foods in the DASH diet, with a corresponding increase in fat and a reduction in sugar intake, on blood pressure and plasma lipids and lipoproteins.

Design: This was a 3-period randomized crossover trial in free-living healthy individuals who consumed in random order a control diet, a standard DASH diet, and a higher-fat, lower-carbohydrate modification of the DASH diet (HF-DASH diet) for 3 wk each, separated by 2-wk washout periods. Laboratory measurements, which included lipoprotein particle concentrations determined by ion mobility, were made at the end of each experimental diet.

Results: Thirty-six participants completed all 3 dietary periods. Blood pressure was reduced similarly with the DASH and HF-DASH diets compared with the control diet. The HF-DASH diet significantly reduced triglycerides and large and medium very-low-density lipoprotein (VLDL) particle concentrations and increased LDL peak particle diameter compared with the DASH diet. The DASH diet, but not the HF-DASH diet, significantly reduced LDL cholesterol, HDL cholesterol, apolipoprotein A-I, intermediate-density lipoprotein and large LDL particles, and LDL peak diameter compared with the control diet.

Conclusions: The HF-DASH diet lowered blood pressure to the same extent as the DASH diet but also reduced plasma triglyceride and VLDL concentrations without significantly increasing LDL cholesterol. This trial was registered at clinicaltrials.gov as NCT01404897.

Keywords: DASH diet; blood pressure; dairy; lipoproteins; saturated fat; triglyceride.

Figures

FIGURE 1
FIGURE 1
Participant recruitment flow.
FIGURE 2
FIGURE 2
Differences between diets in systolic and diastolic BP. *P < 0.017, **P < 0.001. Values are means ± SEs, adjusted for dietary period; n = 36. Data were analyzed by ANOVA for a 3-treatment crossover design. BP, blood pressure; DASH, Dietary Approaches to Stop Hypertension diet; HF-DASH, high-fat, low-carbohydrate DASH diet.
FIGURE 3
FIGURE 3
Differences between diets for plasma triglycerides (A), VLDL concentrations (large, medium, small) (B), and LDL peak diameter (C). *P < 0.017, **P < 0.001. Values are means ± SEs, adjusted for dietary period; n = 36. Data were analyzed by ANOVA for a 3-treatment crossover design. DASH, Dietary Approaches to Stop Hypertension diet; HF-DASH, high-fat, low-carbohydrate DASH diet.

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