Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites

Ju Yeon Song; Young Ji Yoo; Si-Kyu Lim; Sun Ho Cha; Ji-Eun Kim; Jung-Hye Roe; Jihyun F Kim; Yeo Joon Yoon

doi:10.1016/j.jbiotec.2015.12.028

Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites

J Biotechnol. 2016 Feb 10:219:57-8. doi: 10.1016/j.jbiotec.2015.12.028. Epub 2015 Dec 21.

Authors

Ju Yeon Song¹, Young Ji Yoo², Si-Kyu Lim³, Sun Ho Cha³, Ji-Eun Kim⁴, Jung-Hye Roe⁴, Jihyun F Kim⁵, Yeo Joon Yoon⁶

Affiliations

¹ Department of Systems Biology and Division of Life Sciences, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
² Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
³ GenoTech Corporation, 26-69 Gajeongbuk-ro, Daejeon 34113, Republic of Korea.
⁴ School of Biological Sciences and Institute of Microbiology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
⁵ Department of Systems Biology and Division of Life Sciences, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea; Strategic Initiative for Microbiomes in Agriculture and Food, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address: jfk1@yonsei.ac.kr.
⁶ Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. Electronic address: joonyoon@ewha.ac.kr.

PMID: 26718561
DOI: 10.1016/j.jbiotec.2015.12.028

Abstract

Streptomyces venezuelae ATCC 15439, which produces 12- and 14-membered ring macrolide antibiotics, is a platform strain for heterologous expression of secondary metabolites. Its 9.05-Mb genome sequence revealed an abundance of genes involved in the biosynthesis of secondary metabolites and their precursors, which should be useful for the production of bioactive compounds.

Keywords: Actinomycetes; Methymycin; Natural products; Pikromycin; Secondary metabolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Composition
Genome Size
Genome, Bacterial*
Secondary Metabolism
Sequence Analysis, DNA / methods*
Streptomyces / genetics*