Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections

Eur J Pharmacol. 2016 Feb 5;772:33-42. doi: 10.1016/j.ejphar.2015.12.038. Epub 2015 Dec 23.

Abstract

Invasive fungal infections (IFI) are important complications of cancer, and they have become a major cause of morbidity and mortality in cancer patients. Effective anti-infection therapy is necessary to inhibit significant deterioration from these infections. However, they are difficult to treat, and increasing antifungal drug resistance often leads to a relapse. Curcumin, a natural component that is isolated from the rhizome of Curcuma longa plants, has attracted great interest among many scientists studying solid cancers over the last half century. Interestingly, curcumin provides an ideal alternative to current therapies because of its relatively safe profile, even at high doses. To date, curcumin's potent antifungal activity against different strains of Candida, Cryptococcus, Aspergillus, Trichosporon and Paracoccidioides have been reported, indicating that curcumin anticancer drugs may also possess an antifungal role, helping cancer patients to resist IFI complications. The aim of this review is to discuss curcumin's dual pharmacological activities regarding its applications as a natural anticancer and antifungal agent. These dual pharmacological activities are expected to lead to clinical trials and to improve infection survival among cancer patients.

Keywords: Anticancer activity; Antifungal activity; Curcumin; Invasive fungal infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antifungal Agents / pharmacokinetics
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Curcumin / pharmacokinetics
  • Curcumin / pharmacology*
  • Curcumin / therapeutic use
  • Drug Delivery Systems
  • Humans
  • Mycoses / complications*
  • Mycoses / drug therapy*
  • Neoplasms / complications*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / pathology

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Curcumin