Glycine transporter2 inhibitors: Getting the balance right

Robert J Vandenberg; Shannon N Mostyn; Jane E Carland; Renae M Ryan

doi:10.1016/j.neuint.2015.12.007

Glycine transporter2 inhibitors: Getting the balance right

Neurochem Int. 2016 Sep:98:89-93. doi: 10.1016/j.neuint.2015.12.007. Epub 2015 Dec 23.

Authors

Robert J Vandenberg¹, Shannon N Mostyn², Jane E Carland², Renae M Ryan²

Affiliations

¹ Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: robert.vandenberg@sydney.edu.au.
² Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.

PMID: 26723543
DOI: 10.1016/j.neuint.2015.12.007

Abstract

Neurotransmitter transporters are targets for a wide range of therapeutically useful drugs. This is because they have the capacity to selectively manipulate the dynamics of neurotransmitter concentrations and thereby enhance or diminish signalling through particular brain pathways. High affinity glycine transporters (GlyTs) regulate extracellular concentrations of glycine and provide novel therapeutic targets for neurological disorders.

Keywords: Glycine neurotransmission; Glycine transport; Glycine transport inhibitors; Pain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Glycine Plasma Membrane Transport Proteins / antagonists & inhibitors*
Humans
Nervous System Diseases / drug therapy
Nervous System Diseases / physiopathology
Neurotransmitter Agents / metabolism
Signal Transduction / drug effects
Signal Transduction / physiology
Synaptic Transmission / drug effects*

Substances

Glycine Plasma Membrane Transport Proteins
Neurotransmitter Agents