Precision Medicine: Clarity for the Complexity of Dementia

Am J Pathol. 2016 Mar;186(3):500-6. doi: 10.1016/j.ajpath.2015.12.001. Epub 2015 Dec 24.


Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / therapy
  • Cognition Disorders / genetics
  • Cognition Disorders / physiopathology
  • Dementia / genetics
  • Dementia / physiopathology*
  • Humans
  • Mutation
  • Parkinson Disease / genetics
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / therapy
  • Precision Medicine*