doi: 10.1039/c5cc09998f.
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
Affiliations
- PMID: 26725656
- DOI: 10.1039/c5cc09998f
Item in Clipboard
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
Chem Commun (Camb).
.
Abstract
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
Similar articles
-
Mitochondrial thioredoxin reductase purification, inhibitor studies, and role in cell signaling.Methods Enzymol. 2010;474:109-22. doi: 10.1016/S0076-6879(10)74007-6. Epub 2010 Jun 20. Methods Enzymol. 2010. PMID: 20609907
-
Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase.Biochem Biophys Res Commun. 2006 May 12;343(3):873-8. doi: 10.1016/j.bbrc.2006.03.050. Epub 2006 Mar 20. Biochem Biophys Res Commun. 2006. PMID: 16564501
-
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.Mol Cell Biol. 2004 Nov;24(21):9414-23. doi: 10.1128/MCB.24.21.9414-9423.2004. Mol Cell Biol. 2004. PMID: 15485910 Free PMC article.
-
Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors.Free Radic Biol Med. 2018 Nov 1;127:62-79. doi: 10.1016/j.freeradbiomed.2018.03.043. Epub 2018 Mar 27. Free Radic Biol Med. 2018. PMID: 29596885 Review.
-
Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.Free Radic Res. 2011 Jan;45(1):53-8. doi: 10.3109/10715762.2010.509398. Epub 2010 Sep 6. Free Radic Res. 2011. PMID: 20815786 Review.
Cited by
-
Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives.Biosensors (Basel). 2023 Aug 13;13(8):811. doi: 10.3390/bios13080811. Biosensors (Basel). 2023. PMID: 37622897 Free PMC article. Review.
-
6-Shogaol as a Novel Thioredoxin Reductase Inhibitor Induces Oxidative-Stress-Mediated Apoptosis in HeLa Cells.Int J Mol Sci. 2023 Mar 4;24(5):4966. doi: 10.3390/ijms24054966. Int J Mol Sci. 2023. PMID: 36902397 Free PMC article.
-
The Role of the Thioredoxin System in Brain Diseases.Antioxidants (Basel). 2022 Oct 31;11(11):2161. doi: 10.3390/antiox11112161. Antioxidants (Basel). 2022. PMID: 36358532 Free PMC article. Review.
-
Recent Progress on NIR Fluorescent Probes for Enzymes.Molecules. 2022 Sep 12;27(18):5922. doi: 10.3390/molecules27185922. Molecules. 2022. PMID: 36144654 Free PMC article. Review.
-
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.Nat Commun. 2022 Apr 1;13(1):1754. doi: 10.1038/s41467-022-29136-4. Nat Commun. 2022. PMID: 35365603 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
