Magnesium Levels in Drinking Water and Coronary Heart Disease Mortality Risk: A Meta-Analysis

Nutrients. 2016 Jan 2;8(1):5. doi: 10.3390/nu8010005.


Epidemiological studies have demonstrated inconsistent associations between drinking water magnesium levels and risk of mortality from coronary heart disease (CHD); thus, a meta-analysis was performed to assess the association between them. Relevant studies were searched by the databases of Cochrane, EMBASE, PubMed and Web of Knowledge. Pooled relative risks (RR) with their 95% CI were calculated to assess this association using a random-effects model. Finally, nine articles with 10 studies involving 77,821 CHD cases were used in this study. Our results revealed an inverse association between drinking water magnesium level and CHD mortality (RR = 0.89, 95% CI = 0.79-0.99, I² = 70.6). Nine of the 10 studies came from Europe, and the association was significant between drinking water magnesium level and the risk of CHD mortality (RR = 0.83, 95% CI = 0.69-0.98). In conclusion, drinking water magnesium level was significantly inversely associated with CHD mortality.

Keywords: coronary heart disease; magnesium; meta-analysis; mortality.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Adult
  • Aged
  • Coronary Artery Disease / mortality*
  • Drinking Water / chemistry*
  • Female
  • Heart*
  • Humans
  • Magnesium / pharmacology*
  • Male
  • Middle Aged


  • Drinking Water
  • Magnesium