Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Nov 9;2(5):ENEURO.0106-15.2015.
doi: 10.1523/ENEURO.0106-15.2015. eCollection Sep-Oct 2015.

In Vivo Reprogramming for Brain and Spinal Cord Repair

Affiliations
Free PMC article
Review

In Vivo Reprogramming for Brain and Spinal Cord Repair

Gong Chen et al. eNeuro. .
Free PMC article

Abstract

Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC.

Keywords: NG2 cell; astrocyte; brain repair; in vivo; neuron; reprogramming.

Conflict of interest statement

The authors report no conflicts of interest.

Similar articles

See all similar articles

Cited by 14 articles

See all "Cited by" articles

References

    1. Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S (2011) Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9:113-118. 10.1016/j.stem.2011.07.002 - DOI - PMC - PubMed
    1. Andersen J, Urbán N, Achimastou A, Ito A, Simic M, Ullom K, Martynoga B, Lebel M, Göritz C, Frisén J, Nakafuku M, Guillemot F (2014) A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells. Neuron 83:1085-1097. 10.1016/j.neuron.2014.08.004 - DOI - PMC - PubMed
    1. Barker RA, Barrett J, Mason SL, Björklund A (2013) Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease. Lancet Neurol 12:84-91. 10.1016/S1474-4422(12)70295-8 - DOI - PubMed
    1. Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Götz M (2010) In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7:744-758. 10.1016/j.stem.2010.11.017 - DOI - PubMed
    1. Bergles DE, Roberts JD, Somogyi P, Jahr CE (2000) Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405:187-191. 10.1038/35012083 - DOI - PubMed

Publication types

LinkOut - more resources

Feedback