A versatile water-soluble chelating and radical scavenging platform

Chem Commun (Camb). 2016 Feb 7;52(11):2350-3. doi: 10.1039/c5cc08198j.


The phenol-diamide compound, 5-(tert-butyl)-2-hydroxy-N1,N3-bis(2-hydroxyethyl)isophthalamide (), is water-soluble, non-cytotoxic, and capable of both, trapping ROS species and chelating Cu(ii) and Fe(iii) ions; these combined properties confer a protective effect against ROS induced cell death.

MeSH terms

  • Chelating Agents / chemistry*
  • Free Radical Scavengers / chemistry*
  • Solubility
  • Water / chemistry*


  • Chelating Agents
  • Free Radical Scavengers
  • Water