Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Jan 5;6(1):e008166.
doi: 10.1136/bmjopen-2015-008166.

Acupuncture Point Injection Treatment of Primary Dysmenorrhoea: A Randomised, Double Blind, Controlled Study

Affiliations
Free PMC article
Randomized Controlled Trial

Acupuncture Point Injection Treatment of Primary Dysmenorrhoea: A Randomised, Double Blind, Controlled Study

C Wade et al. BMJ Open. .
Free PMC article

Abstract

Objective: To determine if injection of vitamin K3 in an acupuncture point is optimal for the treatment of primary dysmenorrhoea, when compared with 2 other injection treatments.

Setting: A Menstrual Disorder Centre at a public hospital in Shanghai, China.

Participants: Chinese women aged 14-25 years with severe primary dysmenorrhoea for at least 6 months not relieved by any other treatment were recruited. Exclusion criteria were the use of oral contraceptives, intrauterine devices or anticoagulant drugs, pregnancy, history of abdominal surgery, participation in other therapies for pain and diagnosis of secondary dysmenorrhoea. Eighty patients with primary dysmenorrhoea, as defined on a 4-grade scale, completed the study. Two patients withdrew after randomisation.

Interventions: A double-blind, double-dummy, randomised controlled trial compared vitamin K3 acupuncture point injection to saline acupuncture point injection and vitamin K3 deep muscle injection. Patients in each group received 3 injections at a single treatment visit.

Primary and secondary outcome measures: The primary outcome was the difference in subjective perception of pain as measured by an 11 unit Numeric Rating Scale (NRS). Secondary measurements were Cox Pain Intensity and Duration scales and the consumption of analgesic tablets before and after treatment and during 6 following cycles.

Results: Patients in all 3 groups experienced pain relief from the injection treatments. Differences in NRS measured mean pain scores between the 2 active control groups were less than 1 unit (-0.71, CI -1.37 to -0.05) and not significant, but the differences in average scores between the treatment hypothesised to be optimal and both active control groups (1.11, CI 0.45 to 1.78) and (1.82, CI 1.45 to 2.49) were statistically significant in adjusted mixed-effects models. Menstrual distress and use of analgesics were diminished for 6 months post-treatment.

Conclusions: Acupuncture point injection of vitamin K3 relieves menstrual pain rapidly and is a useful treatment in an urban outpatient clinic.

Trial registration number: NCT00104546; Results.

Keywords: acupuncture; dysmenorrhea; menstruation; pain; vitamin k.

Figures

Figure 1
Figure 1
In two of the groups injections were in the Spleen 6 (SP6)/San Yin Jiao (SYJ) acupuncture point near the ankle on both legs. In the third group the injection site was near but not on SP6.
Figure 2
Figure 2
Flow of participants through the study (SP6, Spleen 6; SYJ, San Yin Jiao).
Figure 3
Figure 3
Pain intensity at baseline and in the first hour after treatment (SP6, Spleen 6).

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Harlow SD, Park M. A longitudinal study of risk factors for the occurrence, duration and severity of menstrual cramps in a cohort of college women. Br J Obstet Gynaecol 1996;103:1134–42. 10.1111/j.1471-0528.1996.tb09597.x - DOI - PubMed
    1. Klein JR, Litt IF. Epidemiology of adolescent dysmenorrhea. Pediatrics 1981;68:661–4. - PubMed
    1. Dawood MY. Dysmenorrhea. Clin Obstet Gynecol 1990;33:168–78. 10.1097/00003081-199003000-00023 - DOI - PubMed
    1. Latthe PM, Champaneria R, Khan KS. Dysmenorrhoea. BMJ Clin Evid 2011;2011:pii: 0813. - PMC - PubMed
    1. Marjoribanks J, Proctor ML, Farquhar C. Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea. Cochrane Database Syst Rev 2003;(4):CD001751. - PubMed

Publication types

Associated data

Feedback