A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations

Xinlong Pang; Chao Chen; Ming Li; Chanjuan Xi

doi:10.3762/bjoc.11.258

A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations

Beilstein J Org Chem. 2015 Nov 30:11:2365-9. doi: 10.3762/bjoc.11.258. eCollection 2015.

Authors

Xinlong Pang¹, Chao Chen², Ming Li³, Chanjuan Xi²

Affiliations

¹ Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Tel: +86-10-62773684; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
² Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, Tel: +86-10-62773684.
³ College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Abstract

A series of functionalized benzimidazo[1,2-c]quinazoline derivatives was obtained in excellent yields under mild conditions through a CuI-catalyzed Ullmann N-arylation starting from easily available starting materials.

Keywords: (bromophenyl)iodonium salt; Ullmann N-arylation; benzimidazo[1,2-c]quinazoline; copper catalyst; o-cyanoaniline; quinazolin-4(3H)-imine.