Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes

N Kolevzon; D Hashoul; S Naik; A Rubinstein; E Yavin

doi:10.1039/c5cc07502e

Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes

Chem Commun (Camb). 2016 Feb 7;52(11):2405-7. doi: 10.1039/c5cc07502e.

Authors

N Kolevzon¹, D Hashoul¹, S Naik¹, A Rubinstein¹, E Yavin¹

Affiliation

¹ The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel. eylony@ekmd.huji.ac.il.

PMID: 26735489
DOI: 10.1039/c5cc07502e

Abstract

Peptide nucleic acid bis-quinoline conjugates are reported as attractive far-red emitting probes that detect mutated mRNA in living cells at SNP resolution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microscopy, Fluorescence
Molecular Probes
Neoplasms / genetics*
Peptide Nucleic Acids / chemistry
Point Mutation*
Polymorphism, Single Nucleotide
Spectrophotometry, Ultraviolet

Substances

Molecular Probes
Peptide Nucleic Acids