Characterization of a plasmid coding for resistance to broad-spectrum cephalosporins in Salmonella typhimurium

Drugs Exp Clin Res. 1989;15(4):145-50.

Abstract

Five strains of Salmonella typhimurium isolated from faeces of infants hospitalized at Trousseau Hospital in Paris have been found to be resistant to third-generation cephalosporins. This resistance is by a transferable plasmid-mediated mechanism. The beta-lactamase gene which encodes for an enzyme similar to SHV-2 has been cloned into plasmid pBR322 and expressed in Escherichia coli RR1.

MeSH terms

  • Cefotaxime / pharmacology
  • Ceftazidime / pharmacology
  • Cephalosporins / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Humans
  • Isoelectric Focusing
  • Kinetics
  • Penicillin G / pharmacology
  • Phenotype
  • Plasmids
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / isolation & purification
  • Transformation, Genetic

Substances

  • Cephalosporins
  • DNA, Bacterial
  • Ceftazidime
  • Cefotaxime
  • Penicillin G