[Research Progress in Membrane Fusion of the Respiratory Syncytial Virus]

Bing Du Xue Bao. 2015 Sep;31(5):565-72.
[Article in Chinese]

Abstract

The respiratory syncytial virus (RSV) is one of the most common causes of acute infection of the lower respiratory tract among children. For viruses in the Paramyxoviridae subfamily, membrane fusion requires a specific interaction between two glycoproteins: the fusion protein and attachment protein. Membrane fusion of the RSV appears to be unique among paramyxoviruses in that fusion is accomplished by the fusion protein alone without help from the attachment protein. Here, we review recent achievements and advances in the study of membrane fusion triggered by the RSV published in high-impact-factor journals. We also review and make a comparative analysis of the popular hypotheses regarding membrane fusion of the RSV. Finally, we discuss the "hot topics" in current research and controversial data published in recent years in the hope of providing references for Chinese researchers.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Respiratory Syncytial Virus Infections / virology*
  • Respiratory Syncytial Viruses / genetics
  • Respiratory Syncytial Viruses / physiology*
  • Viral Fusion Proteins / genetics
  • Viral Fusion Proteins / metabolism
  • Virus Internalization*

Substances

  • Viral Fusion Proteins