Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan 7;529(7584):37-42.
doi: 10.1038/nature16187.

Autophagy Maintains Stemness by Preventing Senescence

Affiliations

Autophagy Maintains Stemness by Preventing Senescence

Laura García-Prat et al. Nature. .

Abstract

During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age, this decline is maximal owing to transition from a normal quiescence into an irreversible senescence state. How satellite cells maintain quiescence and avoid senescence until advanced age remains unknown. Here we report that basal autophagy is essential to maintain the stem-cell quiescent state in mice. Failure of autophagy in physiologically aged satellite cells or genetic impairment of autophagy in young cells causes entry into senescence by loss of proteostasis, increased mitochondrial dysfunction and oxidative stress, resulting in a decline in the function and number of satellite cells. Re-establishment of autophagy reverses senescence and restores regenerative functions in geriatric satellite cells. As autophagy also declines in human geriatric satellite cells, our findings reveal autophagy to be a decisive stem-cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia.

Similar articles

See all similar articles

Cited by 273 articles

See all "Cited by" articles

References

    1. J Microsc. 2006 Dec;224(Pt 3):213-32 - PubMed
    1. Nat Rev Cancer. 2014 Aug;14(8):547-58 - PubMed
    1. Autophagy. 2008 Feb;4(2):151-75 - PubMed
    1. Genes Cells. 2013 Jan;18(1):32-41 - PubMed
    1. Annu Rev Genet. 2009;43:67-93 - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources

Feedback