Antimicrobial peptides and wound healing: biological and therapeutic considerations

Abstract

Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

Keywords: antibiotic resistance; antimicrobial peptide; frog skin; innate immunity; skin infections; wound healing.

Figure 1

Schematic representation of biological functions of AMPs, beneficial for wound healing