Antibodies as stratagems against cancer

Mol Biosyst. 2016 Jun 21;12(7):2047-55. doi: 10.1039/c5mb00699f.


Antibodies have been in the frontline of anticancer research during the last few decades, since a number of different ways have been discovered to utilize them as parts or main components of anticancer drugs. Antibodies are used as the only component of some anticancer drugs, but they can also be conjugated with a variety of substances. Antibody engineering methods such as humanization, chimerization and Fc engineering are applied in order to modify their properties according to the requirements of anticancer drug application. Given the continuous advances in biology and informatics, the role of antibodies in anticancer treatment is expected to be prominent.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies / genetics
  • Antibodies / pharmacology
  • Antibodies / therapeutic use*
  • Antibodies, Monoclonal / genetics
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Drug Discovery
  • Humans
  • Immunoconjugates / pharmacology
  • Immunoconjugates / therapeutic use
  • Neoplasms / drug therapy*
  • Protein Engineering


  • Antibodies
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Immunoconjugates