The expanding repertoire of receptor activity modifying protein (RAMP) function

Crit Rev Biochem Mol Biol. 2016;51(1):65-71. doi: 10.3109/10409238.2015.1128875. Epub 2016 Jan 6.


Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.

Keywords: CLR; G-protein; GPCR; desensitization; ligand; signaling; trafficking.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Ligands
  • Phylogeny
  • Protein Binding
  • Receptor Activity-Modifying Proteins / metabolism
  • Receptor Activity-Modifying Proteins / physiology*
  • Signal Transduction


  • Ligands
  • Receptor Activity-Modifying Proteins