Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

Eur J Med Res. 2016 Jan 8;21:1. doi: 10.1186/s40001-015-0194-5.

Abstract

Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).

Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained.

Results: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min(-1)); 18.5 ± 1.5 (5 L min(-1)); 21.7 ± 1.7 (10 L min(-1)); 24.0 ± 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air.

Conclusions: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Blood Gas Analysis
  • Blood Pressure
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Exercise / physiology*
  • Exercise Test / methods
  • Feasibility Studies
  • Heart Rate
  • Humans
  • Hydrogen-Ion Concentration
  • Hyperoxia*
  • Male
  • Middle Aged
  • Oxygen / blood*
  • Oxygen Consumption
  • Pressure

Substances

  • Oxygen