Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil

J Gastrointest Cancer. 2017 Mar;48(1):66-69. doi: 10.1007/s12029-015-9797-x.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites, Antineoplastic / adverse effects
  • Antimetabolites, Antineoplastic / therapeutic use
  • Capecitabine / adverse effects*
  • Capecitabine / therapeutic use
  • Dihydropyrimidine Dehydrogenase Deficiency / metabolism*
  • Dose-Response Relationship, Drug
  • Fluorouracil / administration & dosage*
  • Humans
  • Male
  • Middle Aged
  • Rectal Neoplasms / drug therapy
  • Rectal Neoplasms / metabolism

Substances

  • Antimetabolites, Antineoplastic
  • Capecitabine
  • Fluorouracil