Rebooting autoimmunity with autologous HSCT

Blood. 2016 Jan 7;127(1):8-10. doi: 10.1182/blood-2015-11-678607.

Abstract

Autologous hematopoietic stem cell transplantation (HSCT) is increasingly used for severe autoimmune and inflammatory diseases, but the mechanisms involved have yet to be elucidated. In this issue of Blood, Delemarre et al report their findings in both animal and human models which provide insights into restoration of functionality and diversity within the regulatory T-cell (Treg) compartment following HSCT.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / therapy*
  • Bone Marrow Transplantation*
  • Female
  • Forkhead Transcription Factors / physiology*
  • Humans
  • Inflammation / immunology*
  • Receptors, Antigen, T-Cell / immunology*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Forkhead Transcription Factors
  • Receptors, Antigen, T-Cell