Mortality in Children Aged 0-9 Years: A Nationwide Cohort Study from Three Nordic Countries

PLoS One. 2016 Jan 8;11(1):e0146669. doi: 10.1371/journal.pone.0146669. eCollection 2016.

Abstract

Background: Mortality in children under five years has been widely studied, whereas mortality at 5-9 years has received little attention. Using unique data from national registers in three Nordic countries, we aimed to characterize mortality directionality in children aged 0 to 9 years.

Methods and findings: The cohort study included all children born in Denmark from 1973 to 2008 (n = 2,433,758), Sweden from 1973 to 2006 (n = 3,400,212), and a random sample of 89.3% of children born in Finland from 1987 to 2007 (n = 1,272,083). Children were followed from 0 to 9 years, and cumulative mortality and mortality rates were compared by age, gender, cause of death, and calendar periods. Among the 7,105,962 children, there were 48,299 deaths during study period. From 1981-1985 to 2001-2005, all-cause mortality rates were reduced by between 34% and 62% at different ages. Overall mortality rate ratio between boys and girls decreased from 1.25 to 1.21 with the most prominent reduction in children aged 5-9 years (from 1.59 to 1.19). Neoplasms, diseases of the nervous system and transport accidents were the most frequent cause of death after the first year of life. These three leading causes of death declined by 42% (from 6.2 to 3.6 per 100,000 person years), 43% (from 3.7 to 2.1) and 62% (from 3.9 to 1.5) in boys, and 25% (from 4.1 to 3.1 per 100000 person years), 42% (from 3.4 to 1.9) and 63% (from 3.0 to 1.1) in girls, respectively. Mortality from neoplasms was the highest in each age except infants when comparing cause-specific mortality, and half of deaths from diseases of the nervous system occurred in infancy. Mortality rate due to transport accidents increased with age and was highest in boys aged 5-9 years.

Conclusions: Mortality rate in children aged 0-9 years has been decreasing with diminished difference between genders over the past decades. Our results suggest the importance of further research on mortality by causes of neoplasms, and causes of transport accidents-especially in children aged 5-9 years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents, Traffic / mortality*
  • Child
  • Child Mortality
  • Child, Preschool
  • Denmark / epidemiology
  • Female
  • Finland / epidemiology
  • Humans
  • Infant
  • Infant Mortality
  • Infant, Newborn
  • Male
  • Neoplasms / mortality*
  • Sweden / epidemiology

Grant support

This study was supported by a grant from the European Commission’s Seventh Framework Programme/European Research Council (ERC-2010-StG-260242-PROGEURO to JL) http://ec.europa.eu/research/fp7/index_en.cfm. Data recruitment was supported by grants from the Danish Medical Research Council (project no. 09-072986 to JL) http://ufm.dk/site/english/councils-commissions-committees/scientific-research-councils/the-danish-medical-research-council, the Swedish Council for Working Life and Social Research (Grant no. 2010-0092 to SC) http://www.forte.se/en/, the Nordic Cancer Union (2013-78760 to JL) http://www.ncu.nu/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.