The role of hyaluronan in the pathobiology and treatment of respiratory disease

Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L785-95. doi: 10.1152/ajplung.00168.2015. Epub 2016 Jan 8.


Hyaluronan, a ubiquitous naturally occurring glycosaminoglycan, is a major component of the extracellular matrix, where it participates in biological processes that include water homeostasis, cell-matrix signaling, tissue healing, inflammation, angiogenesis, and cell proliferation and migration. There are emerging data that hyaluronan and its degradation products have an important role in the pathobiology of the respiratory tract. We review the role of hyaluronan in respiratory diseases and present evidence from published literature and from clinical practice supporting hyaluronan as a novel treatment for respiratory diseases. Preliminary data show that aerosolized exogenous hyaluronan has beneficial activity against airway inflammation, protects against bronchial hyperreactivity and remodeling, and disrupts the biofilm associated with chronic infection. This suggests a role in airway diseases with a predominant inflammatory component such as rhinosinusitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, and primary ciliary dyskinesia. The potential for hyaluronan to complement conventional therapy will become clearer when data are available from controlled trials in larger patient populations.

Keywords: asthma; bacterial biofilm; chronic obstructive pulmonary disease; cystic fibrosis; hyaluronan; inflammation; respiratory tract diseases.

Publication types

  • Review
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Humans
  • Hyaluronic Acid / physiology*
  • Hyaluronic Acid / therapeutic use
  • Lung / metabolism
  • Lung / pathology*
  • Respiratory Tract Diseases / drug therapy
  • Respiratory Tract Diseases / metabolism*
  • Respiratory Tract Diseases / pathology
  • Signal Transduction


  • Anti-Inflammatory Agents
  • Hyaluronic Acid