Dramatic Expansion of HSCs: New Possibilities for HSC Transplants?

Sarah Nikiforow; Jerome Ritz

doi:10.1016/j.stem.2015.12.011

Dramatic Expansion of HSCs: New Possibilities for HSC Transplants?

Cell Stem Cell. 2016 Jan 7;18(1):10-2. doi: 10.1016/j.stem.2015.12.011.

Authors

Sarah Nikiforow¹, Jerome Ritz²

Affiliations

¹ Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
² Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: jerome_ritz@dfci.harvard.edu.

PMID: 26748750
DOI: 10.1016/j.stem.2015.12.011

Abstract

The identification of mechanisms that regulate stem cell renewal has led to the development of innovative approaches to expand hematopoietic stem cells ex vivo. One approach reported by Wagner et al. (2016) in this issue of Cell Stem Cell has demonstrated dramatic expansion of umbilical cord blood stem cells that promote rapid engraftment while maintaining capacity for long-term hematopoiesis.

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MeSH terms

Cells, Cultured
Fetal Blood
Hematopoiesis
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans